A variation of your question has a positive answer. If you take any compact manifold that is a smooth bundle over another compact manifold $\pi : M \to N$, there is a smooth embedding $$f : M \to N \times \mathbb R^k$$ giving a commutative diagram i.e. such that $pr_1 \circ f = \pi$, for some $k$ usually fairly large. There's a lot of ways of proving this, but if you know about the theory of classifying spaces it follows from the observation that if $F$ is the fibre of $f$, then $BDiff(F)$$ can be thought of as the space $$Emb(F, \mathbb R^\infty) / Diff(F)$$ The space is the limit $Emb(F, \mathbb R^\infty) = \lim_k Emb(F, \mathbb R^k)$ induced by the inclusions $\mathbb R^k \to \mathbb R^{k+1}$. The proof is an old argument of Whitney's, basically a variation of the weak Whitney embedding theorem, that $Emb(F, \mathbb R^k)$ is highly connected provided $k$ is large. Off the top of my head I don't remember the connectivity, but it's about $\lceil \frac{k}{2} -dim(F) - 1\rceil$, i.e. the greatest integer less than or equal to the above. Making $k$ small is analogous to the question of asking the question of what is the smallest dimensional Euclidean space a manifold embeds into. You are basically asking that question "with parameters". In your specific case the vector space is one dimension larger than your fiber sphere $S^n$. So from this point of view your question is asking about the pseudoisotopy diffeomorphism group of the sphere. When $M$ is a circle, such embeddings do not exist due to Cerf's pseudoisotopy theorem. You are interested in if the map from the pseudoisotopy diffeomorphism group to the vanilla diffeomorphism group can be non-trivial $PDiff(S^n) \to Diff(S^n)$. Some people would also phrase the question of if you can construct (families) of diffeomorphisms of $S^n$ that are pseudoisotopically trivial. I believe the diffeomorphisms of $S^4$ constructed by Watanabe are pseudoisotopically trivial. In his original paper he has a non-constructive argument, but he may very well have a constructive argument in follow-on papers. https://www.math.kyoto-u.ac.jp/~tadayuki.watanabe/Diff_S4.pdf I have a "soon to appear" paper where we write down the null pseudo-isotopies constructively, i.e. you can see them at a point-set level. So Watanabe's construction would answer your question when $N = S^2$ and the fiber is $S^4$. But there are several papers published in the past few years that likely have analogous results for $N$ a broad range of spheres and the fiber being high-dimensional spheres. I would start maybe looking at the papers of Alexander Kupers. edit: Regarding the reduction, given an embedding $S^n \to \mathbb R^{n+1}$, this embedding is known to bound a smoothly-embedded $D^{n+1}$ provided $n \neq 3$. This is the Schoenflies problem. When $n=3$ you still have the Jordan separation theorem, so a $3$-sphere bundle bounds a bundle whose fibers are homotopy $D^4$'s. Anyhow, so this largely reduces the question to when a diffeomorphism of $S^n$ extends to a diffeomorphism of $D^{n+1}$. For this there is the observation that $Diff(S^n)$ has the homotopy-type of $O_{n+1} \times Diff(D^n)$. Similarly $Diff(D^{n+1})$ has the homotopy-type of $O_{n+1} \times PDiff(D^n)$. It's basically the same argument. This makes the fibration $Diff(D^{n+1}) \to Diff(S^n)$ equivalent to the product map $O_{n+1} \times PDiff(D^n) \to O_{n+1} \times Diff(D^n)$ where the map $O_{n+1} \to O_{n+1}$ is the identity, and $PDiff(D^n) \to Diff(D^n)$ is the pseudoisotopy fibration (restriction to the free portion of the boundary). This argument appears in my "A family of embedding spaces" paper, but I believe this general type of argument goes back to Cerf's first papers on pseudoisotopy. Regarding proving $BDiff(M) \simeq Emb(M, \mathbb R^{\infty}) / Diff(M)$, this is just the weak Whitney embedding theorem with parameters. We want to argue $Emb(M, \mathbb R^\infty)$ is contractible, i.e. a model for $EDiff(M)$. So take a map $S^k \to Emb(M, \mathbb R^\infty)$ and try to bound it by a map $D^{k+1} \to Emb(M, \mathbb R^\infty)$. The idea is to use the straight-line homotopy to construct such an extension, and then perturb the homotopy to be a family of embeddings.