I really don't think this is a problem.

If there's a good / logical reason to combine the papers (and such a thing is possible by timing), that's fine.  But there might be many reasons why it's not appropriate - in addition to what you mentioned above, there might be two different sets of coauthors on the different papers, which can also make it tricky...

However, if paper #2 has already submitted/accepted/published/not easily combine-able, then I think you should resubmit #1 at your convenience, to whatever journal is most appropriate.  I wouldn't worry about paper #2 really at all in this decision.

In many subfields of mathematics, dissemination of results now happens largely on the arXiv.  Thus I think where / when the articles get published is becoming less and less important (although the prestige of an article in a good or top journal can still be useful for career reasons).

I've certainly been in situations like this and it hasn't seemed to be a problem.  I've also been a referee of papers in this position (both #1 and #2).  In the reports for papers #2, I usually note something like: "this paper builds on the work of paper #1 which appeared 3 years ago on the arXiv...."