No. In fact, every Lebesgue measurable function $f\colon I\to E$ is equal almost everywhere to a limit of simple Lebesgue measurable functions. As you hint at in the question, this is easy to show in the case where $E$ is separable. The general situation reduces to the separable case due to the following result. For a full proof, see Fremlin, *Measure Theory*, Volume 4 Part I, Lemma 451Q. > **Theorem 1:** Let $(X,\Sigma,\mu)$ be a finite compact measure space, $Y$ a metrizable space, and $f\colon X\to Y$ a measurable function. Then, there is a closed separable subspace $Y_0$ of $Y$ such that $f^{-1}(Y\setminus Y_0)$ is negligible. That is, $f$ has essentially separable image. Restricting $f$ to the complement of a negligible set reduces the problem to the situation where the codomain is separable, in which case it is a limit of simple functions. Compactness of the space $(X,\Sigma,\mu)$ means that there is a family $\mathcal{K}\subseteq\Sigma$ such that any subset of $\mathcal{K}$ with the [finite intersection property][1] has nonempty intersection, and such that $\mu$ is [inner-regular][2] with respect to $\mathcal{K}$. That is, $\mu(E)=\sup\{\mu(K)\colon K\in\mathcal{K},K\subseteq E\}$ for every $E\in\Sigma$. In particular, the Lebesgue measure is compact by taking $\mathcal{K}$ to be the collection of compact sets under the standard topology. The proof of Theorem 1 is rather tricky, involving what Fremlin describes as "non-trivial set theory". It rests on the following two results. > **Theorem 2:** Any metrizable space has a $\sigma$-disjoint base $\mathcal{U}$. That is, $\mathcal{U}$ is a base for the topology, and can be written as $\bigcup_{n=1}^\infty\mathcal{U}_n$ where each $\mathcal{U}_n$ is a disjoint collection of sets. (Fremlin, *Measure Theory*, Volume 4 II, 4A2L (g-ii)) > **Theorem 3:** Let $(X,\Sigma,\mu)$ be a finite compact measure space and $\{E_i\}\_{i\in I}$ be a disjoint family of subsets of $X$ such that $\bigcup_{i\in J}E_i\in\Sigma$ for every $J\subseteq I$. Then, $\mu\left(\bigcup_{i\in I}E_i\right)=\sum_{i\in I}\mu(E_i)$. (Fremlin, *Measure Theory*, Volume 4 I, 451P). Theorem 3 is particularly remarkable, as it extends the countable additivity of the measure to arbitrarily large unions of sets. Once these two results are known, the proof that $f$ has essentially separable image in Theorem 1 is straightforward. Let $\mathcal{U}=\bigcup_{n=1}^\infty\mathcal{U}_n$ be a $\sigma$-disjoint base for $Y$. Let $\mathcal{V}_n$ be the collection of $U\in\mathcal{U}_n$ such that $\mu(f^{-1}(U)) = 0$. By countable additivity, $\mathcal{U}_n\setminus\mathcal{V}_n$ is countable. Also, $\{f^{-1}(U)\colon U\in\mathcal{V}_n\}$ is a disjoint collection of negligible subsets of $X$ and, by measurability of $f$, any union of a subcollection of these is measurable. It follows from Theorem 3 that its union is negligible. That is, $f^{-1}\left(\bigcup\mathcal{V}_n\right)$ is negligible. Setting $Y_0=Y\setminus\bigcup_n\bigcup\mathcal{V}_n$ then, by countable additivity, $f^{-1}(Y\setminus Y_0)$ is negligible. Also, $\bigcup_n(\mathcal{U}_n\setminus\mathcal{V}_n)$ restricts to a countable base for the topology on $Y_0$, so it is separable (in fact, it is second-countable). Finding a $\sigma$-disjoint base for the topology on $Y$ is easy enough. Following Fremlin, you can do this by well-ordering $Y$ and letting $(q_n,q^\prime_n)$ be a sequence running through the pairs $(q,q^\prime)$ of rationals with $0 < q < q^\prime$. Letting $\mathcal{U}\_n$ be the collection of sets of the form $$ G_{ny}=\left\{x\in Y\colon d(x,y) < q_n, \inf\_{z < y}\\,d(x,z) > q_n^\prime\right\} $$ (over $y\in Y$) gives a $\sigma$-disjoint base. The really involved part of the proof is in establishing Theorem 3. I suggest you look in Fremlin for the details, but the idea is as follows. By countable additivity, only countably many $E_i$ can have positive measure so, removing these, we can suppose that every $E_i$ is negligible. Also, restricting $X$ to the union of the $E_i$ if necessary, we can suppose that $X=\bigcup\_iE_i$. Then define the function $f\colon X\to I$ by $f(x)=i$ for $x\in E_i$. Using the power set $\mathcal{P}I$ for the sigma-algebra on $I$, $f$ will be measurable. Then let $\nu=\mu\circ f^{-1}$ be the image measure on $(I,\mathcal{P}I)$. Fremlin breaks this down into two cases. a) $\nu$ is atomless. As with any finite atomless measure space, there will be a measure preserving map $g\colon I\to[0,\gamma]$ for some $\gamma > 0$, using the Lebesgue measure $\lambda$ on $[0,\gamma]$. Using compactness, it can be shown that the sets on which $\lambda$ and $\nu\circ g^{-1}$ are well-defined coincide (precisely, $\mu$ is compact, so it is [perfect][3], so $\nu\circ g^{-1}$ is perfect and therefore is [Radon][4]). The existence of non-Lebesgue sets will then give a contradiction unless $\gamma=0$, so $\mu(X)=0$. b) $\nu$ has an atom $M\subseteq I$: In this case, $\mathcal{F}=\{F\subseteq M\colon\nu(M\setminus F)=0\}$ is a non-principal ultrafilter on $M$ which is closed under countable intersections. Again making use of compactness of $\mu$, this can be used to derive a contradition, but it requires some tricky set theory. I refer you to Fremlin (451P) for the full details of this argument. [1]: http://en.wikipedia.org/w/index.php?title=Finite_intersection_property&oldid=347936770 [2]: http://en.wikipedia.org/w/index.php?title=Inner_regular_measure&oldid=316455240 [3]: http://eom.springer.de/P/p072070.htm [4]: http://eom.springer.de/R/r077170.htm