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What is the "Tangle" at the Heart of Quantum Simulation?

The following questions generalize and naturalize the question that was originally asked. Provisional answers largely due to Will Sawin are now included. As was discussed in the question originally ...
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Intractability of an integral by deterministic numerical methods

Suppose $X_1,\ldots,X_n$ is an i.i.d. sample from a probability distribution with continuous c.d.f. $F.$ Let $F_n$ be the empirical c.d.f. $$ F_n(x) = \frac 1 n \sum_{k=1}^n \mathbf 1_{X_n\le x} = \...
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