# Questions tagged [bioinformatics]

The bioinformatics tag has no usage guidance.

13
questions

2
votes

1
answer

90
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### Proof of dynamic programming calculation of Levenshtein distance

Let s1 and s2 are 2 arbitrary strings with lengths l1 and ...

0
votes

0
answers

67
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### Texts on coalescent theory/probability methods for DNA evolution

I am starting a PhD on mitochondrial evolution modelling with a focus on probabilistic methods and coalescent theory. For this purpose, I am looking for
advanced textbooks on probability methods for ...

3
votes

1
answer

180
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### Distribution of the change in Hamming distance between two sequences

Suppose I have two strings $s_1$ and $s_2$ of equal length $L$ with an alphabet size of $k \geq 2$. Suppose further that these two strings initially have a Hamming distance equal to $d_0 = H(s_1,s_2)$....

1
vote

0
answers

41
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### Mathematical modeling of multi-site reaction-diffusion

(I asked a similar question on Mathematics SE, but based on the Help section it might be better suited for this site, as it is focused on research-level mathematical modeling.)
I am wondering if ...

3
votes

1
answer

193
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### Matching two sequences between each other

Given the sequence of symbols $A$ (contains ~10,000 symbols) and sequence of blocks $B$ (contains ~3,000 blocks, ~30 symbols inside each block) I need to exclude some blocks from sequence $B$ so that ...

6
votes

2
answers

858
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### Human brains considered as directed graphs

I assume that human brains can be considered as directed graphs with neurons as nodes and synapses as edges. I explicitly don't want to consider the weights, the dynamics of neural activity (based on ...

5
votes

2
answers

541
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### Neighbourhood of a word and Levenshtein distance

The Levenshtein distance or Edit distance $$ lev(U,V) $$ between two strings $U$ and $V$ over a finite alphabet $\Sigma$ of size $ \left| \Sigma \right| = \sigma ,$ is the minimal number of insertions,...

4
votes

2
answers

1k
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### Industry jobs involving mathematics, machine learning and biology [closed]

I have a MSc in Mathematics and a PhD in Bioinformatics (in two different European countries); during the PhD I was developing computational methods to analyse DNA sequence data, mainly using a ...

0
votes

1
answer

158
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### Generating spatially-aware degree-preserving random graphs?

In the study of biological neural networks, researchers sometimes compare hypotheses vs. a degree-preserving random null model. One major criticism against this approach is that connections in neural ...

1
vote

1
answer

333
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### Maximal difference between k randomly drawn numbers from 1 to n – Looking for formula to sequence

Hello!
I have an interesting problem that seemed simple to me, but I'm unable to solve it on my own.
Suppose I am drawing k numbers out of n numbers labeled from 1 to n.
Considering all $\binom{n}{k}$...

3
votes

1
answer

523
views

### Cover a line segment randomly with smaller line segments

Covering a circle randomly with arcs has been well studied in the past (Geometric Probability - Solomon).
But the problem when the circle is changed to a line segment doesn't seem to have been ...

8
votes

3
answers

507
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### MicroArray, tesing if a sample is the same with high variance data.

I'll explain the problem but what I am looking for is a few suggested methods to approach this problem.
You don't need to know what a microarray but if you are interested look here link text
The info ...

4
votes

3
answers

2k
views

### Correspondence between Viterbi algorithm and Smith-Waterman

Viterbi is an algorithm for finding the maximum likelihood assignment to the hidden variables of an HMM, given the observed variables (we know the transition and emission probabilities of the HMM). ...