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The title is a talk given by Sir M. Atiyah in a conference with the following abstract: I will explain a deep analogy between 4-dimensional smooth geometry (Donaldson theory)...

The $E_8$ Cartan matrix is given by, $$ K_{E_8}=\begin{pmatrix} 2 & -1 & 0 & 0 & 0 & 0 & 0 & 0 \\ -1 & 2 & -1& 0 & 0 & 0 & 0 & 0 \\ ...

In an old answer to an old question of mine, Peter Teichner commented that it is an open problem to determine which homotopy 2-types arise from 4-manifolds. In some instances we know that a 4-manifold ...