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Computation of $\pi_1$ for a Mazur manifold and its boundary
If we attach a $4$-dimensional $1$-handle $D^1 \times D^3$ to a $4$-dimensional $0$-handle $B^4$, we obtain $S^1 \times D^3$. The null homologous knot in $S^1 \times S^2$ indicated in the picture ...