Homotopy Groups of Connected Sums This was sparked because I wanted to compute $\pi_2(Sym^2(\Sigma_2))$ via $Sym^2(\Sigma_2)\approx \mathbb{T}^4$# $\bar{\mathbb{C}P}^2$.
We know how to compute $\pi_1$ of $M$ # $N$ via van-Kampen's theorem. But what about higher homotopy groups? I looked in the literature and google without luck, and so I am wondering if no such procedure exists.  Are there any results for calculating $\pi_n$ of connected sums?
There was mention of "higher van Kampen theorem"... has this actually been used to do such computations? I'd be interested in references if not just examples.
 A: Just a comment on the role of the Higher Homotopy Seifert-van Kampen Theorems:
they should be regarded as an extra tool in algebraic topology. There are quite severe conditions on their applicability but when they apply they compute quite a lot. Just as the 1-dimensional theorem, in its groupoid formulation, is about calculating 1-types, so the 2-dim theorem is about computing 2-types, in the form of crossed modules (over groupoids). However computing the second homotopy group from this 2-type may not be straightforward. But then the situation is the same for the 1-dim theorem, as is evidenced by the complications of theorems such as the Kurosh subgroup theorem, which can be seen to be  about the fundamental group(s) of a cover of a wedge of $K(G_i,1)$'s. 
As a taster, based on the 2-d theorem, work with Chris Wensley enabled the computation of the crossed module representing the 2-type of the mapping cone of a map $Bf: BG \to BH$ induced by a morphism $f: G \to H$. Of course. the second homotopy group, even as a module over the fundamental group, is but a pale shadow of the 2-type. You can see some of this in our book (pdf available from my web page on the book). 
R. Brown, P.J. Higgins, R. Sivera,  Nonabelian algebraic
topology: filtered spaces, crossed complexes, cubical homotopy
groupoids, EMS Tracts in Mathematics Vol. 15, 703 pages. (August
2011).
November 8, 2013: As a taster, let $X$ be the homotopy pushout  of the classifying spaces of the two maps of groups $P \to P/M, P \to P/N$ where $M,N$ are normal subgroups of the group $P$. The the homotopy 2-type of $X$ is determined by the crossed module $M \circ N \to P$, the coproduct of the two crossed $P$-modules, which is given by the pushout of crossed modules 
$$\begin{matrix} (1 \to P) & \to & (N \to P) \cr
\downarrow && \downarrow \cr 
(M \to P)& \to  & (M \circ N \to P)
\end{matrix} $$. It follows that 
$$ \pi_2(X) \cong (M \cap N)/ [M,N]. $$
(Of course we know $\pi_1 X$ by the 1-dimensional van Kampen Theorem.) This result is applied in Bardakov, Valery G; Mikhailov, Roman; Vershinin, Vladimir V.; Wu, Jie, 
"Brunnian braids on surfaces". Algebr. Geom. Topol. 12 (2012), no. 3, 1607–1648. 
A: The 2nd homotopy group of a connect sum is fairly reasonable to compute.  $\pi_i X$ is isomorphic to $\pi_i \tilde X$ provided $i \geq 2$ and $\tilde X$ indicates any covering space of $X$, so we might as well take the universal cover.  By the Hurewicz theorem, $\pi_2 \tilde X$ is isomorphic to $H_2 \tilde X$.  In the case of a connect sum, the universal cover has a very nice description (take disjoint unions of the universal covers of the punctured manifolds and glue them together appropriately).  
Since $\mathbb CP^2$ is simply connected this is a fairly easy thing to compute.  The universal cover looks like $\mathbb R^4$ with a $\mathbb CP^2$ summand at every integer lattice point. So,  
$$\pi_2 ((S^1)^4 \# \mathbb CP^2) \simeq \bigoplus_{\pi_1 T^4} \pi_2 \mathbb CP^2$$
i.e. a direct sum over $\mathbb Z^4$ of copies of the integers, i.e. $\mathbb Z[t_1^\pm, t_2^\pm, t_3^\pm, t_4^\pm]$ a laurent polynomial ring in four variables.  $\pi_1$ acts by multiplication by units in the Laurent polynomial ring.  
Higher homotopy groups in general can be fairly painful to compute but $\pi_2$ is usually quite reasonable, like this case. 
A: Here is something that's valid in the stable range.
If $M$ and $N$ are closed $n$-manifolds, there is a cofibration sequence
$$
S^{n-1} \to M_0 \vee N_0 \to M\sharp N
$$
where $M_0$ denotes the effect of deleting a point from $M$.  
If $M$ and $N$ are $r$-connected, then so is the connected sum. The Blakers-Massey excision theorem then implies an exact sequence
$$
\pi_k(S^{n-1}) \to \pi_k(M_0 \vee N_0) \to \pi_k(M\sharp N) \to \pi_{k-1}(S^{n-1}) \to \cdots
$$
as long as $k \le n-2+r$. 
Furthermore the map $M_0 \vee N_0 \to M_0 \times N_0$ is $(2r+1)$-connected, so if 
$k \le 2r$ we get $\pi_k(M_0 \vee N_0) = \pi_k(M) \oplus \pi_k(N)$. 
Assembling this, we have an exact sequence 
$$
\pi_k(S^{n-1}) \to \pi_k(M) \oplus \pi_k(N) \to \pi_k(M\sharp N) \to \pi_{k-1}(S^{n-1}) \to \cdots
$$
which is valid for $k \le 2r$, $r \le n-2$.
Added Later
I just realized one could simply note that the cofiber sequence gives a long exact sequence on stable homotopy
$$
\pi_k^{st}(S^{n-1}) \to \pi_k^{st}(M_0) \oplus \pi_k^{st}(N_0) \to \pi_k^{st}(M\sharp N) \to \pi_{k-1}^{st}(S^{n-1}) \to \cdots
$$
and then if $M$ and $N$ are $r$-connected with $k \le 2r$ and $r\le n-2$ we can use the Freudenthal suspension theorem to identify the stable groups with the corresponding unstable ones.  This gives a more elementary argument.
Here's a special case: when $M$ and $N$ are framed, so is $M\sharp N$ and the connecting map in the exact sequence splits to give a splitting
$$
 \pi_k(M\sharp N) = \pi_k(M) \oplus \pi_k(N) \oplus \pi_{k-1}(S^{n-1}) 
$$ 
(assuming the constraints on $k,r$ and $n$).
