Let $F\rightarrow X\rightarrow B$ be a fibration. If we know very well the spaces $F$ and $B$ and wish to compute the homology of $X$. One possible tool is the Serre Spectral Sequence. However, it works under the condition that $\pi_1(B)$ acts trivially on $H_*(F;G)$. If this condition ($\pi_1(B)$ acts trivially on $H_*(F;G)$) does not hold, what other tools can one use to compute the homology of the homology of $X$?

In fact I am interested in the special case that all spaces in the fibration are $K(\pi,1)$ spaces. If any approach works for this particular case it would be wonderful.

Thank you!