Pi1-sentence independent of ZF, ZF+Con(ZF), ZF+Con(ZF)+Con(ZF+Con(ZF)), etc.? Let
ZF1 = ZF,
ZFk+1 = ZF + the assumption that ZF1,...,ZFk are consistent,
ZFω = ZF + the assumption that ZFk is consistent for every positive integer k,
... and similarly define ZFα for every computable ordinal α.
Then a commenter on my blog asked a question that boils down to the following: can we give an example of a Π1-sentence (i.e., a universally-quantified sentence about integers) that's provably independent of ZFα for every computable ordinal α?  (AC and CH don't count, since they're not Π1-sentences.)
An equivalent question is whether, for every positive integer k, there exists a computable ordinal α such that the value of BB(k) (the kth Busy Beaver number) is provable in ZFα.
I apologize if I'm overlooking something obvious.
Update: I'm grateful to François Dorais and the other answerers for pointing out the ambiguity in even defining ZFα, as well as the fact that this issue was investigated in Turing's thesis.  Emil Jeřábek writes: "Basically, the executive summary is that once you manage to make the question sufficiently formal to make sense, then every true Π1 formula follows from some iterated consistency statement."
So, I now have a followup question: given a positive integer k, can we say something concrete about which iterated consistency statements suffice to prove the halting or non-halting of every k-state Turing machine?  (For example, would it suffice to use ZFα for some encoding of α, where α is the largest computable ordinal that can be defined using a k-state Turing machine?)
 A: This should be a comment since I don't know the answer, but you might like this article:
http://xorshammer.com/2009/03/23/what-happens-when-you-iterate-godels-theorem/
It discusses $PA_\alpha$ for ordinal $\alpha$ and mentions things get messy above $\alpha=\omega$.
A: In 1939, Alan Turing investigated such questions [Systems of logic based on ordinals, Proc. London Math. Soc. 45, 161-228]. It turns out that one runs into problems rather quickly due to the fact that the $(\omega+1)$-th such theory is not completely well-defined. Indeed, there are many ordinal notations for $\omega+1$ and these can be used to code a lot of information.
Turing's Completeness Theorem. If $\phi$ is a true $\Pi_1$ sentence in the language of arithmetic, then there is an ordinal notation $a$ such that $|a| = \omega+1$ and $T_a$ proves $\phi$.
This result applies to any sound recursively axiomatized extension $T$ of $PA$. In particular, this applies to (the arithmetical part of) $ZF$.
To avoid this, one might carefully choose a path through the ordinal notations, but this leads to a variety of other problems [S. Feferman and C. Spector, Incompleteness along paths in progressions of theories, J. Symbolic Logic 27 (1962), 383–390]. 
A: I think there is some vagueness inherent in the "similarly define ...".  How is one to assign the consistency statement $Con(ZF_\lambda)$ for computable $\lambda$? This looks trivial but it is not.
I think also ZF is something of a red herring here. The question arises in PA (since we are looking at $\Pi_1$ sentences quantifying over natural numbers.)
Feferman has shown ("Transfinite Recursive Progression of Theories" JSL 1962) that it is possible to assign for every n in an effective manner a $\Sigma_1$-formula $\varphi_n(v_0)$ where each of the latter is to be thought of as enumerating (integer codes of) axiom sets (which I'll call "theories.").  This is done in such a fashion so that if $a,b$ are integers with $b = 2^a$  that $T_b$ is $T_a$ together with the statement 
$$\forall \psi \in \Sigma_1\forall x [ Prov_{T_a}\psi(x) \longrightarrow \psi(x)]$$
(This is thus a "1-Reflection Principle"  - for $\psi\in\Sigma_1$ here). He does this
with a view to considering those integers $a$ that are notations for recursive ordinals (in the sense of the notation system devised by Kleene - "Kleene's $O$".)
 (There are clauses for $a$ representing a notation for a limit ordinal, when $a = 3^e$).
He proves that there are linear paths through the system of notations of computable ordinals, going through all recursive ordinals $\alpha$,so that
Every true $\Pi_2$
sentence in arithmetic is proven by one of the theories along the path.
The starting
theory $T_0$ here can be PA (or ZFC if you want).  Such a path gives
a definite meaning to $ZF_0, \ldots, ZF_\alpha, \ldots$ etc. for recursive $\alpha$.
Moreover for such a particular progression of theories one would would construe the answer to the question to be "No". 
Feferman's starting point was the 1939 paper of Turing ("On Systems of Logic Based on Ordinal"). Turing also considered such paths through Kleene's $O$, but could just prove a theorem for $\Pi_1$ sentences, (using simpler "Consistency" statements"). Feferman shows that if one takes "$n$-Reflection" statements 
for every $n$ each time one extends the theory then there are paths along which every true statement of
arithmetic is proven.
The moral of the story is that there are very complex ways of simply defining sequences
of theories, (because there are infinitely many ways, or Turing programs, of representing a recursive ordinal) which can hide/disguise all sorts of information.
A very readable survey is Franzen: "On Transfinite Progressions" BSL 2004.
Update (This is an answer to Scott Aaronson's Update.)
He asks:
given a positive integer k, can we say something concrete about which iterated consistency statements suffice to prove the halting or non-halting of every k-state Turing machine? 
Let $M_0, \ldots ,M_{n-1}$ enumerate the $k$-state TM's. Let $P$ be the subset of $n$
of those indices of TM's in the list that halt.
The statement 
$\forall i (i \in P \rightarrow M_i$  halts $ \wedge \,
 i \notin P \rightarrow M_i $ does not halt $)$    
is a $\Pi_2$ statement. In Feferman's paper (op.cit.) he shows that every true
$\Pi_2$ statement is proven by a theory $T_a$ in a 1-Reflection sequence, where $a$ is a notation for an ordinal of rank equal to $\omega^2 + \omega + 1 $. 
So in terms of the question we do not need to vary the $\alpha$ depending on what
ordinals a $k$-state machine can produce. (Just fix $\alpha$ as given 
above.) Of course it gives us zero practical information: there are infinitely many such notations of that rank, and we may not know which one to look at.
