The assumption implies that the natural embedding induces an isomorphism $\Gamma(X,\mathscr O_X)\simeq \Gamma(\overline X,\mathscr O_{\overline X})$. Then this means that the complement of $X$ has at least codimension $2$.

In addition assume that $X$ is noetherian and $S_2$ (for instance normal).

In this case *if* $\Omega_{\overline X}$ is a reflexive sheaf, then the restriction
$\Gamma(\overline X,\Omega_{\overline X})\to \Gamma(X,\Omega_{\overline X})=\Gamma(X,\Omega_{X})$ is an isomorphism.

More generally, let $Z:=\overline X\setminus X$. If $\mathrm{depth}_Z\Omega_{\overline X}\geq 2$ then the restriction $\Gamma(\overline X,\Omega_{\overline X})\to \Gamma(X,\Omega_{X})$ is an isomorphism.
This certainly holds if $\Omega_{\overline X}$ is a reflexive sheaf, but obviously it could hold "by accident" even if one of the above conditions fail, so I am not claiming that these are necessary conditions, but at least they sure seem to provide a natural set of conditions under which the required map is an isomorphism.

**Sketch** that if $X$ is $S_2$, then a *reflexive* coherent sheaf $\mathscr F$ is also $S_2$:
First observe that by the argument in this answer to another MO question we may assume that $X$ is affine and it is enough to prove that $H^i_x(X,\mathscr F)=0$ for $i=0,1$ for all $x\in X$ and it also follows that $\mathrm{depth}_Z\mathscr F\geq 2$ even if $Z$ is not contained in an affine piece of $X$. To do that write $\mathscr F^\vee$ as the quotient of a (locally) free sheaf ($X$ is affine!). Then $\mathscr F$ is a submodule of the dual of this locally free sheaf, let's call it $\mathscr E$, and the quotient $\mathscr E/\mathscr F$ is torsion-free. Therefore none of them have torsion and so $H^0_x(X,\mathscr F)=0$ and $H^1_x(X,\mathscr F)$ embeds into $H^1_x(X,\mathscr E)$. But the latter is $0$ by the assumption that $X$ is $S_2$.

**EDIT 1** removed intro paragraph about the starting assumption.

**EDIT 2** added "more generally" paragraph.

**EDIT 3** added noetherian assumption. this is probably not necessary but without this one should possibly be more careful about the other conditions.

**EDIT 4** Added **Sketch** above.

openinclusion, so it induces an isomorphism of schemes onto an open subscheme. $\endgroup$ – Greg Muller Mar 6 '11 at 3:05