The following result of Howe [Perspectives on invariant theory: Schur duality, multiplicity-free actions and beyond] answers this completely:
Let $\mathfrak{g}$ be a finite-dimensional simple complex Lie algebra. Then a non-trivial irreducible $\mathfrak{g}$-module $V(\lambda)$ has one-dimensional weight spaces if and only if
- $\lambda$ is minuscule,
- $\lambda$ is quasi-minuscule and $\mathfrak{g}$ has only one short simple root,
- $\mathfrak{g}=C_{3}=\mathfrak{sp}_{6}$ and $\lambda=\omega_{3}$, or
- $\mathfrak{g}=A_{l}=\mathfrak{sl}_{l+1}$ and $\lambda=m\omega_{1}$ or $\lambda=m\omega_{l}$ for some $m\in \mathbb{N}$.
I was able to find this via a paper of Stembridge [Multiplicity-free products and restrictions of Weyl characters].
As I needed exactly this property in a paper of my own, you will find definitions of minuscule and quasi-minuscule as well as references from which I drew a table of these on pages 20-21 of it (arXiv:0409359, On Lie induction and the exceptional series). They are as follows, taken from [Visual basic representations: An atlas] by Plotkin–Semenov–Vavilov:
Non-zero minuscule weights:
$\begin{array}{ll}
A_{l} & \omega_{i},\ 1\leq i \leq l \\
B_{l} & \omega_{l} \\
C_{l} & \omega_{1} \\
D_{l} & \omega_{1},\ \omega_{l-1},\ \omega_{l} \\
E_{6} & \omega_{1},\ \omega_{6} \\
E_{7} & \omega_{7}
\end{array} $
Quasi-minuscule weights:
$ \begin{array}{ll}
\begin{array}[t]{ll} A_{l} & [1,0,0,\ldots,0,1]\ (\mbox{adjoint}) \\
B_{l} & \omega_{1} \\
C_{l} & \omega_{2} \\
D_{l} & \omega_{2} \\
E_{6} & \omega_{2} \\
E_{7} & \omega_{1} \\
E_{8} & \omega_{8} \\
F_{4} & \omega_{4} \\
G_{2} & \omega_{1}
\end{array}
\end{array} $