$a(54)=1943156261=127\times653\times23431.$
Because
$$
m=11854443675453271=41\times2089\times 4093\times4253\times7951$$
and
$$\prod_{p\mid m}\frac{p+4}{p+2}=\frac{43}{41},$$
it implies that
$$a(21)\leq11854443675453271<1.2\times10^{16}.$$
Claim 1. $\omega(a(21))\leq 7$ where $\omega(N)=\sum_{p\mid N}1.$
Proof. Let $\omega(a(21))=r$ and $a(21)=p_1p_2\cdots p_r,$ where $p_1<p_2<\cdots<p_r$. Noting that
$$\frac{43}{41}=\prod_{i=1}^r\frac{p_i+4}{p_i+2}\geq\left(\frac{p_i+4}{p_i+2}\right)^i=\left(1+\frac{2}{p_i+2}\right)^i\geq 1+\frac{2i}{p_i+2},$$
we obtain
$$p_i\geq41i-2$$
and
$$1.2\times10^{16}>a(21)=\prod_{i=1}^{r}p_i\geq\prod_{i=1}^{r}(41i-2).$$
Since $\prod_{i=1}^{8}(41i-2)>2.8\times10^{17}$, it leads to $$r\leq 7.$$
Remark. It can be proven that if an odd squarefree number $m$ satisfies $\omega(m)=r$ and $\prod_{p\mid m}\frac{p+4}{p+2}=\frac{2n+1}{2n-1}$, then $m<(8(2n-1))^{2^r-1}.$
Claim 2. If $\omega(a(21))=5$ and $a(21)=p_1p_2\cdots p_5,$ where $p_1<p_2<\cdots<p_5$, then $p_5\leq 8467.$
Proof
From Daniel Weber's comment, it follows that
$$6.8\times10^{11}>a(21)=p_5\prod_{i=1}^{4}p_i\geq p_5\prod_{i=1}^{4}(41i-2)=61158240p_5.$$
So $$p_5<11119.$$
Since $$\frac{43}{41}=\prod_{i=1}^5\frac{p_i+4}{p_i+2}$$
there exist $1\leq i,j\leq5$ such that
$$p_i+2 \equiv 0\pmod{41},$$
$$p_j+4 \equiv 0\pmod{43}.$$
If $i=j$ then $p_5\geq p_i=p_j\geq 14143$, this contradicts $p_5\leq 11119.$
Therefore $i\neq j$ and $p_i\geq367, p_j\geq 211.$ Hence, $p_4\geq 211$ and
$$6.8\times10^{11}>a(21)=p_5p_4\prod_{i=1}^{3}p_i\geq 211p_5\prod_{i=1}^{3}(41i-2)=79656720p_5.$$
So $$p_5\leq 8467.$$
a(75) exists.
$$a(75)\leq507578951905423=449\times 557\times 727\times 1103\times 2531.$$
Theorem 1. If an odd squarefree number $m$ satisfies $\omega(m)=r$ and $\prod_{p\mid m}\frac{p+4}{p+2}=\frac{2n+1}{2n-1}$, then $r \equiv 1 \pmod 2.$
Proof. Suppose $r \equiv 0 \pmod 2$, $m=\prod_i^rp_i$. In the set $\{p_1,\cdots, p_r\}$ there are $s$ numbers that are congruent to $1\pmod4$ and $ t$ numbers that are congruent to $-1\pmod4$.
Noting that$\frac{2n+1}{2n-1}=\prod_{i=1}^r\frac{p_i+4}{p_i+2}$, we have
$$2n=\frac{\prod_{i=1}^r(p_i+4)+\prod_{i=1}^r(p_i+2)}{\prod_{i=1}^r(p_i+4)-\prod_{i=1}^r(p_i+2)}.$$
Clearly,
$$\prod_{i=1}^r(p_i+4)+\prod_{i=1}^r(p_i+2)\equiv\prod_{i=1}^r(p_i+4)-\prod_{i=1}^r(p_i+2)\equiv0\pmod 2.$$
Since $s+t=r\equiv 0 \pmod 2$, we have
$$\prod_{i=1}^r(p_i+4)+\prod_{i=1}^r(p_i+2)\equiv (-1)^t+3^s\equiv(-1)^t+(-1)^s\not\equiv0\pmod4 $$
and
$$\prod_{i=1}^r(p_i+4)-\prod_{i=1}^r(p_i+2)\equiv (-1)^t-3^s\equiv(-1)^t-(-1)^s\equiv0\pmod4 .$$
Hence
$$2n=\frac{\prod_{i=1}^r(p_i+4)+\prod_{i=1}^r(p_i+2)}{\prod_{i=1}^r(p_i+4)-\prod_{i=1}^r(p_i+2)} \not \in \mathbb{Z}.$$
This contradiction led to $r \equiv 1 \pmod 2.$ QED
I have verified that $$a(75) = 507578951905423=449\times 557\times 727\times 1103\times 2531 \approx 5.08\times10^{14}.\tag{1}$$
We provide a proof for $(1)$. By Theorem 1, $\omega(a(75))$ is an odd number. Clearly, $\omega(a(75))\neq 1$. Similar to Claim 1, we have
$\omega(a(75))\leq 5.$
Claim 3. $\omega(a(75))=5.$
Proof. We only need to prove that $\omega(a(75))\neq 3.$ Suppose $\omega(a(75))=3$ and $a(75)=p_1p_2p_3$ where $3\leq p_1<p_2<p_3$. Similar to Claim 1, we have $p_i\geq i(2n-1)-2=149i-2$. So $p_1\geq 149$ and $p_2\geq307.$
If $p_1\geq 443$, then $p_2\geq449$, $p_3\geq 457$ and
$$\frac{151}{149}=\prod_{i=1}^3\frac{p_i+4}{p_i+2}\leq\frac{447}{445}\times\frac{453}{451}\times\frac{461}{459}=\frac{10372039}{10235445}<\frac{151}{149}.$$
Hence
$$149\leq p_1\leq 439.$$
If $p_2\geq 22787$, then $p_3\geq22807$ and
$$\frac{151}{149}=\prod_{i=1}^3\frac{p_i+4}{p_i+2}\leq\frac{153}{151}\times\frac{22791}{22789}\times\frac{22811}{22809}<\frac{151}{149}.$$
Hence
$$307\leq p_2\leq 22783.$$
Therefore, under the conditions $149\leq p_1\leq 439$ and $307\leq p_2\leq 22783$, we solve for the prime solution $p_3$ of the equation $\frac{151}{149}=\prod_{i=1}^3\frac{p_i+4}{p_i+2}$. That is, check whether $$p_3=\frac{147 p_{1} p_{2}+890 p_{1}+890 p_{2}+4164}{p_{1} p_{2}-147 p_{1}-147 p_{2}-890}\tag{2}$$ is a prime number. After computer checks, the equation $(2)$ has no solution. Hence $\omega(a(75))\neq 3.$ QED
Claim 4. $$a(75) = 507578951905423=449\times 557\times 727\times 1103\times 2531.$$
Proof. By Claim 3, We have $\omega(a(75))=5$. Let $a(75)=\prod_{i=1}^5p_i$ where $3\leq p_1<p_2<\cdots<p_5.$ From $p_i\geq i(2n-1)-2=149i-2$, we obtain
$$p_1\geq149,p_2\geq307,p_3\geq449,p_4\geq599.$$
We will now determine the upper bound for $p_i$ where $1\leq i \leq 4.$
If $p_1\geq 739$, then $p_2\geq743$, $p_3\geq 751$, $p_4\geq 757$, $p_5\geq 761$ and
$$\frac{151}{149}=\prod_{i=1}^5\frac{p_i+4}{p_i+2}\leq\frac{743}{741}\times\frac{747}{745}\times\frac{755}{753}\times\frac{761}{759}\times\frac{765}{763}<\frac{151}{149}.$$
Hence
$$149\leq p_1\leq 733.$$
Since
$$507578951905423\geq a(75)=\prod_{i=1}^5p_i\geq149p_2(p_2+2)(p_2+4)(p_2+6),$$
$$507578951905423\geq a(75)=\prod_{i=1}^5p_i\geq149\times307p_3(p_3+2)(p_3+4),$$
$$507578951905423\geq a(75)=\prod_{i=1}^5p_i\geq149\times307\times449p_4(p_4+2),$$
we obtain
$$p_2\leq1327,p_3\leq 2221,p_4\leq4969.$$
Therefore, under the conditions $149\leq p_1\leq 733$, $307\leq p_2\leq 1327$, $449\leq p_3\leq 2221$ and $599\leq p_4\leq 4969$, we solve for the prime solution $p_5$ of the equation $\frac{151}{149}=\prod_{i=1}^5\frac{p_i+4}{p_i+2}$. That is, check whether $$p_5=
\frac{596\prod_{i=1}^4(p_i+4)-302\prod_{i=1}^4(p_i+2)}{151\prod_{i=1}^4(p_i+2)-149\prod_{i=1}^4(p_i+4)}\tag{3}$$ is a prime number. After computer verification and calculations, we obtain $$a(75) = 507578951905423=449\times 557\times 727\times 1103\times 2531.$$ QED