EDIT: In comments, with thanks to Maxime Ramzi, this question has a good answer in that what I want to be true is true when $\mathscr{A}$ satisfies axiom $\mathsf{AB}5$, that $\mathscr{A}$ is cocomplete and filtered colimits are exact. I suppose a new question is: is the truth of my question for $\mathscr{A}$ equivalent to exactness of filtered colimits in $\mathscr{A}$?
$\newcommand{\A}{\mathscr{A}}\newcommand{\tot}{\operatorname{Tot}^{\oplus}}$Weibel claims that if $\A$ is an Abelian category then, for a bounded below complex (of homological type) $C$ and any Cartan-Eilenberg resolution $Q$ of $C$, the map $\tot Q\to C$ is a quasiisomorphism. This is not too hard to show by a chase. However, as a side remark he mentions that we need $\A$ to be cocomplete to form $\tot Q$ in general - which I of course agree with - but the exact phrasing suggested he also believes $\tot Q\to C$ is a quasiisomorphism in that case. I don't believe this is true, and it was a bit ambiguous for me in the text.
Specifically, the obstruction is this: (letting $C$ be an unbounded complex) diagram chasing needs to be handled with care in Abelian categories. There is the formalism of what Mac Lane calls generalised members and we can use these to do a lot but it is important to remember these are not really elements of sets. The difficulty in the unbounded case is, in showing homological injectivity and demonstrating if a cycle of $\tot Q$ is a boundary in $C$ it must be a boundary in $\tot Q$ (forcing us to actually construct the boundary member):
Suppose two members $x,y\in_m\bigoplus_{i\in J}X_i$ have the "same" components, meaning $\pi_jx\equiv\pi_j y$ for all $j\in J$. Must it follow that $x\equiv y$?
I believe this boils down to the following subquestion:
Under what conditions on $\A$ is it true that if $a,b:Y\to\bigoplus_{i\in J}X_i$ are two arrows with $\pi_ja=\pi_jb$ for all $j$ we have $a=b$?
More technically it would suffice to show this is true for a certain class of $Y$, so long as this class represents all members up to equivalence and is closed under direct sum or something like that. Essentially, I'm asking:
For which Abelian categories is $\bigoplus$ formed by some kind of "finite sum" construction?
I say that because the finite sum construction makes my question hold for categories of modules.