Let $U\subseteq\Bbb R^n$ be an open set and $\gamma\subset U$ a closed null-homotopic curve in $U$ (i.e. it can be contracted to a point). Then is there an embedded disc $D\subset U$ with boundary $\gamma$?
This is a follow up on this question, from which I know the answer for
- $n=2$: Yes, using the Schoenflies theorem.
- $n=3$: No if $\gamma$ is a non-trivial knot. Is it true if $\gamma$ is the unknot?
I am mostly interested in $n=4$ and everything being piecewise linear, but a more general answer is welcome as well.