You need at least three large primes to write every large s as the sum of three squares of primes; there are only about $n / \ln n$ primes below n, therefore only about $n^2 / (2 \cdot \ln^2 n)$ pairs of two primes, therefore much fewer than $n^2 / (2 \cdot \ln^2 n)$ sums of two squared primes less than $n^2$, we need at least $2 \cdot \ln^2 n$ other primes.
Every prime other than 2 or 3 is $6k ± 1$ and its square is $36 k^2 ± 12k + 1$. Using only primes, and each prime only once, $12k + 11$ could be the sum of 4 plus seven squares of larger primes, eight primes in total. Allowing 1 doesn't help. If we allow the same prime multiple then the worst case is $12k + 10$ which can be the sum of 4 and six squares of larger primes. ($12k + 11$ would not be the worst case because it can be 4 + 4 + 3 squares of large primes).
So 8 non-repeating squares and seven possibly repeating squares of primes may be enough to represent all large integers, 7 non-repeating or 6 repeating squares of primes are not.
The only way that $s = 12k + 0$ is the sum of eight or fewer squares of primes is s equal to 9 plus 3 large squares of primes; there are not that many combinations so we can expect quite large $s = 12k$ that are not the sum of four, and therefore not the sum of eight squares.