There are many motivations, but the short answer is that many desirable properties are only available in the world of $\infty$-categories. This is a wonderful miracle.
This is particularly visible when one works with objects up to a notion of equivalence that is coarser than equality or isomorphism. For instance. If we want to work with spaces up to homotopy or with chain complexes up to quasi-isomorphism. The main interest of category theory, when we want more from it than producing a convenient language to express the concept of natural transformation, is that it produces very powerful constructions, namely adjunctions and Kan extensions (they appear for instance in the formation of operations on sheaves, on representations of groups). The problem is that such constructions are known to exist systematically only if we work with categories having sufficiently many (co)limits, whereas the operation of enforcing non-trivial maps to become actual isomorphisms typically destroys the property of having enough (co)limits. This is why classically, we have to perform category theoretic constructions in rigid settings (topological spaces, chain complexes...) and see how they are compatible with our favorite notion of equivalence, which can become tedious.
In contrast, in $\infty$-category, all ordinary categories fit in. In fact, we can do all the usual constructions and theorems of ordinary category hold. For instance, if I consider the category of topological spaces and want to work up to homotopy, I can invert homotopy equivalences formally, exactly as in ordinary category theory (i.e. through a universal property that looks the same at first glance). Except that in the context of $\infty$-categories, this process does not produce an ordinary category any more, but a genuine $\infty$-category, and the latter has all small limits and colimits. Similarly if I want to invert formally quasi-isomorphisms of chain complexes (or, more generally, weak equivalences in any model category structure). That means that we can apply the traditional methods of category theory to our theory of spaces up to homotopy, without going back to the classical category of spaces and wondering if what we are doing is compatible with homotopy equivalences. But the price to pay is that we must work with genuine $\infty$-categories. And then, while we know how to express ordinary mathematics within $\infty$-category theory, we discover new phenomena that have no occurrence in classical mathematics; for instance, there are stable $\infty$-categories, i.e. those in which it is amazingly easy to produce a short exact sequence: $\infty$-categories with finite (co)limits in which the initial and terminal objects coincide and in which a commutative square is a pushout iff it is a pullback (exercise: if this is an ordinary category, it must be equivalent to the category with a unique object and a unique morphism, namely the identity). Such $\infty$-categories do not only exist but are the core of homological algebra (including in the traditional sense) and can be found everywhere. This leads to a more general ambidexterity questions that are extremely fruitful in stable homotopy theory and in representation theory, for instance; but this this simply the foundation of all homological algebra. Another example: one can do geometry in this language, and many moduli spaces get better regularity properties in the higher setting than their truncated counterparts.
At the end of the day, $\infty$-category theory looks very much like ordinary category theory, except that we can always reduce our computations to contexts in which there is only one way to identify objects: isomorphisms. This has to be compared with the zoo:
equality, isomorphism, equivalence of categories, equivalence of 2-categories, homotopy equivalence, quasi-isomorphisms... That turns the process of gluing mathematical objects much more natural (in fact possible) in $\infty$-category theory, which is the basic tool to do any kind of geometry. That is why there is no turning back, I think.