You can always consider the second (distribution) derivative of a continuous function and require that it is non-negative, which means that for all $T\in \mathbb R^n$ and all $\phi\in \mathscr D(\Omega;\mathbb R_+)$
\begin{multline}
\sum_{1\le j,k\le n}\langle \frac{\partial^2u}{\partial x_j\partial x_k}(x)T_k T_j, \phi(x)\rangle_{\mathscr D'(\Omega), \mathscr D(\Omega)}
=
\sum_{1\le j,k\le n}T_k T_j\langle u(x),\frac{\partial^2\phi} {\partial x_j\partial x_k}(x)\rangle_{\mathscr D'(\Omega), \mathscr D(\Omega)}
\\
=\sum_{1\le j,k\le n}T_k T_j\int u(x)\frac{\partial^2\phi} {\partial x_j\partial x_k}(x)dx\ge 0.
\end{multline}
Note also that non-negative distributions are actually Radon measures, so that, for all $T\in \mathbb R^n$,
$$
\sum_{1\le j,k\le n}\frac{\partial^2u}{\partial x_j\partial x_k}(x)T_k T_j
\quad\text{ is a non-negative Radon measure.}
$$
Now, if $\rho$ is a non-negative compactly supported smooth function with integral 1 and $
\rho_\epsilon(x)=\rho(x/\epsilon)\epsilon^{-n},
$
you may require that
$$
u\ast \langle (D^2\rho_\epsilon) T\cdot T\rangle\ge 0,
$$
which is a pointwise condition when $u$ is continuous.