Are the categories of sets, abelian groups, and commutative rings unique? Independence results like the independence of the generalized continuum hypothesis, the Whitehead problem, and the global dimension of $\prod_{n = 1}^\infty \mathbb{F}_2$ from ZFC seem to indicate no. And yet we don't say "Let $\mathbf{Set}$ be a category of sets" instead of "Let $\mathbf{Set}$ be the category of sets," etc. If these categories are not unique, then could they be if we wanted them to? And shouldn't they be unique, if the terms "set," "function," "abelian group," "commutative ring," etc., are to be well-defined?
EDIT: Questions have arisen as to what I mean by "unique". Unique as in one and only one? Unique as in unique up to equivalence of categories? Unique as in unique up to isomorphism of categories? Unique as in unique up to unique isomorphism of categories? Honestly, any of those four senses of "unique" is fine with me. Just pick one and answer that particular question. Does it make sense to consider $\mathbf{Set}$ as a category that is unique in some sense described above?
EDIT (SUMMARY): Answers to this question seem to have been of one of the following flavors.
Monism allows $\mathbf{Set}$ to be unique, but pluralism does not. Some mathematicians are monists, some are pluralists, while others think that both monism and pluralism are respectable philosophies of mathematics. Call these views "monism," "pluralism," and "monist-pluralist dualism."
Just as $\mathbb{Z}$ is unique up to iso in the category of rings, $\mathbf{Set}$ and $\mathbf{Ring}$ are unique up to category equivalence in the meta-category of categories, but there is no sense of uniqueness in an absolute sense. $\mathbb{Z}$ and $\mathbf{Set}$ and $\mathbf{Ring}$ are not unique in an absolute sense. If this is the case, then I'd argue that mathematical truth, too, is not absolute, but rather relative to a theory. Call this view "relativism." This view is new to me. I am not a relativist, at least as yet.
$\mathbb{Z}$ is unique up to iso, $\mathbf{Set}$ and $\mathbf{Ring}$ are unique up to category equivalence, etc. Mathematical truth is absolute and does not mean truth within a theory, and uniqueness is also absolute. Call this view "absolutism."
Conventionally, mathematicians today are operating under the assumptions of ZFC, and ZFC doesn't answer the question in the positive or in the negative, and so the question doesn't have a mathematical answer. Call this view "conventionism".
The answer one gives to the question apparently depends on what philosophical views one holds. But the same is true about questions like, "Is the axiom of choice true," "Does every nontrivial commutative ring have a maximal ideal," "Does every vector space have a basis?" A relativist would say, yes, if one is working under the assumptions of ZFC and the ordinary rules of mathematical proof. An absolutist would just say yes (if they believed that the axioms and theorems of ZFC were true). Others might just say yes, under the tacit assumption that most mathematicians today are operating under the assumptions of ZFC, while remaining agnostic about the status of mathematical truth.
Absolutists might see the question I posted as a valid mathematical question. A problem with asbolutism is that many important questions, like GCH and the Whitehead problem, have not been settled, at least as yet. A problem with relativism is, why are "if-then" statements true? What makes Boolean first-order logic absolute but not the rest of mathematics? Why are any mathematical proofs valid at all? Why not assume some non-Boolean constructive or intuitionistic logic? If my question is not a purely mathematical one and is partly "philosophical" and "open to interpretation", then isn't every mathematical question thus?
These aren't additional questions I'm asking for discussion here. I'm just trying to explain why I thought my question was a valid mathematical question and not a purely philosophical one. Thank you to those who tried to answer it, as your answers have much clarified my thinking about the problem. I've accepted Hamkins' answer because it was least biased, but I welcome other answers to the question and can always change what answer I accept. I felt pressured to accept an answer because of a vote to close the question as inappropriate for MO.