The question is in the title:
Is it possible to define the category of sets using the 'one hom-class' definition without relying on tuples as arrows or another 'typing trick'?
I used to view the 'triples trick' (where we say that an arrow $f$ in a category is actually a triplet $(f,X,Y)$ consisting of the arrow paired with its intended domain/codomain) as an 'artificial typing', used to present 'naturally typed' categories using the one hom-class definition.
A recent embarrasing question of mine, however, made it clear that we can't rely on entire relations in place of functions to specify domains/codomains in the 'one hom-class' definition of a category. This makes me unsure if it's even possible to give an 'untyped' definition of the category of sets, since saying 'the objects are sets and the arrows are functions' leaves us at a loss for how to select codomains using a function unless we 'artificially type' the arrows by viewing them as ordered pairs with the codomain prespecified.
Needless to say, if it isn't possible to define categories like ${\bf Set}$ without somehow 'typifying' the arrows, constructions like the 'triples trick' immediately seem less artificial and more like essential tools for defining categories in a 'one hom-class' fashion.