Suppose that $\mathsf E$ is a countable Borel equivalence relation on the reals, and $\mathsf B$ is a finer equivalence of order 2, so that each $\mathsf E$-class consists of precisely two $\mathsf B$-classes.
Is there a large Borel set $X$ with the property that it intersects not more than one $\mathsf B$-class within each $\mathsf E$-class?
This depends on what large means, of course. If large = perfect, super-perfect, or $\mathsf E_0$-large then the answer is yes (but only modulo some nontrivial canonization theorems in descriptive set theory). What about large = positive measure or large = non-meager? Just interesting.