The classical Catalan numbers $$ C_n = \frac{1}{n+1} \binom{2n}{n}, $$ well-known for their numerous combinatorial interpretations (the second volume of Stanley's Enumerative Combinatorics famously lists a total of 66), essentially arise as the even moments $E[X^{2n}] = \int x^{2n} d\mu$ of the Wigner semicircle distribution $d\mu$: this distribution depends on a parameter $R$, the radius of the semicircle, and in general one has $E[X^{2n}] = (R/2)^{2n} C_n$, so choosing $R=2$ gives precisely the Catalan numbers. (The odd moments are all zero.)
Now, associated to this distribution are a family of very classical orthogonal polynomials: the Chebyshev polynomials of the second kind, $U_n(x)$. (Up to a simple change of variables, $U_n(x)$ coincides with the matching polynomial of the path graph on $n$ vertices; for other interpretations and discussion see this blog post and this MO question.)
In their paper Lectures on the topological recursion for Higgs bundles and quantum curves, O. Dumitrescu and M. Mulase define a sequence of numbers $C_{g,n}(\mu_1,\ldots,\mu_n)$ which they call generalized Catalan numbers. The definition (found on p. 26) is as follows:
Definition: Let $\vec{\Gamma}_{g,n}(\mu_1,\ldots,\mu_n)$ denote the set of arrowed cell graphs drawn on a closed, connected, oriented surface of genus $g$ with $n$ labeled vertices of degrees $\mu_1,\ldots,\mu_n$. Then $$ C_{g,n}(\mu_1,\ldots,\mu_n) := |\vec{\Gamma}_{g,n}(\mu_1,\ldots,\mu_n)|. $$
Below this, the authors justify the terminology by pointing out that $C_{0,1}(2m) = C_m = \frac{1}{m+1} \binom{2m}{m}$.
I don't know much about the story of multivariate orthogonal polynomials, and there are quite a few parameters here, but I can't help but wonder: might there perhaps be some multivariate analogue of the Wigner semicircle distribution, having these quantities $C_{g,n}(\mu_1,\ldots,\mu_n)$ as its (appropriately defined) moments – and with it, a corresponding family of orthogonal polynomials?
I also find it curious that the above paper discusses Laplace transforms, since the (bilateral) Laplace transform is exactly how one passes from a probability density function to its moment-generating function (as one learns in a first course on probability theory.) Admittedly, this is probably just a coincidence.