There is a very natural way to define generators of $\pi_{4n-1}(SO(4n))\cong \mathbb{Z}\oplus \mathbb{Z}$ in terms of quaternions when $n=1$ and octonions when $n=2$ (see for example Tamura, On Pontrjagin classes and homotopy types of manifolds, 1957). Since there are no normed division algebras in higher dimensions, it is not possible to do the same for $n>2$.
I was wondering whether there still is a natural identification between $\pi_{4n-1}(SO(4n))$ and $\mathbb{Z}\oplus\mathbb{Z}$ using explicit generators when $n>2$?