If one wants to understand representations of $\mathfrak{g}$ (a finite dimensional semisimple Lie algebra) of weight $\lambda$, the happiest you could be is if $\lambda+\rho$ is (integral) regular dominant, i.e. it's an element of the weight lattice whose product $\langle \lambda+\rho,\check{\alpha}\rangle$ with every simple coroot $\check{\alpha}$ is a negative integer. In this case there's an equivalence between the category of these representations and twisted $\mathscr{D}$ modules on the flag variety $U(\mathfrak{g})_\lambda\text{-mod}\simeq \mathscr{D}_\lambda\text{-mod}$. See the book by Hotta, Toshiyuki, Tanisaki, section 11.2.
If $\lambda+\rho$ is just (integral) regular (nothing in $W$ stabilises it), there is an equivalence of derived categories. I've not worked with this, but presumably along with translation functors (tensoring with $\mathscr{O}(\mu)$ to make the twist of the $\mathscr{D}$ module dominant) this allows you to use standard Beilinson-Bernstein above to get a handle on such modules.
My question is: what is currently known when $\lambda+\rho$ is non-integral? If it splits up into rational and irrational case (where all $\langle \lambda+\rho,\check{\alpha}\rangle\in\mathbf{Q}$ or otherwise), I am more interested in the rational case.