For Q1 the answer is known to be $\sim C_1C_2^n n^{-5/2} $ for $C_1\approx 0.5349496061...$ and $C_2\approx 2.9955765856...$. This can be found in Flajolet and Sedgewick's "Analytic Combinatorics" (see p.481) with the main ingredients being singularity analysis and the relation
$$I(z)=H(z)-\frac{1}{2}\left(H(z)^2-H(z^2)\right)$$
where $I$ is the generating function for unrooted unlabelled trees and $H$ is the generating function for rooted unlabelled trees. This is all originally from Otter's paper
"The Number of Trees" from Annals of Mathematics, Vol 49, no.3 pp. 583-599.
For Q2, homeomorphism classes of trees on $n$ vertices correspond to homeomorphically irreducible trees (also sometimes called series-reduced tress, or topological trees, see OEIS) of at most $n$ vertices. This enumeration problem appears in the movie Good Will Hunting and there is even a numberphile video about it.
These were enumerated by Harary and Prins in
Frank Harary and Geert Prins, "The number of homeomorphically irreducible trees and other species" Acta Math., 101 (1959), 141-162
and for the asymptotics see
F. Harary, R. W. Robinson and A. J. Schwenk, Twenty-step algorithm for determining the asymptotic number of trees of various species, J. Austral. Math. Soc., Series A, 20 (1975), 483-503
I also believe that both Q1 and Q2 are exposited in the book "Graphical Enumeration" by Harary and Palmer, but I'll have to check.