$\DeclareMathOperator\Aut{Aut}$Wells's exact sequence: if $G$ is a group with normal subgroup $N$, it relates $\Aut(G)$ to $\Aut(N)$ and $\Aut(G/N)$. I'll state it, then explain it; for those who haven't seen it, the notation may make it seem scary, but hopefully my explanation below makes it less scary. It starts with:
$$1 \to Z^1_\alpha(G/N, Z(N)) \to \Aut(G; N) \xrightarrow{f_1} \Aut(N) \times \Aut(G/N).$$
The idea is this: first, we want to restrict our attention to automorphisms of $G$ that send $N$ to itself — this is precisely what $\Aut(G; N)$ is. If we don't do that, things get…complicated. (When $N$ is characteristic, $\Aut(G; N) = \Aut(G)$, so this is a particularly nice case. And if you apply this inductively in a finite group, your base case is characteristically simple groups, whose automorphism groups are easily described.)
Once we have that, we find that any automorphism $\varphi$ also induces an automorphism of the quotient $G/N$, so we certainly get a map from $\Aut(G; N) \to \Aut(N) \times \Aut(G/N)$. This is $f_1$.
Now, what is the kernel of $f_1$? It's exactly the automorphisms of $G$ that fix $N$ pointwise and that induce the trivial automorphism of $G/N$; in other words, all they do is they move around the elements within their respective $N$-cosets. Thus, any such automorphism $\varphi$ is given by a function $c \colon G/N \to N$ such that $\varphi(g) = g \cdot c(\pi(g))$, where $\pi \colon G \to G/N$ is the natural quotient map, and $c(1) = 1$. For $\varphi$ to be a homomorphism (hence isomorphism), it is necessary and sufficient that
$$c(\pi(g) \pi(h)) = h^{-1} c(\pi(g)) h c(\pi(h))$$
for all $g,h \in G$. Applying this equation to arbitrary $h \in N$, we find that we must have $\operatorname{Image}(c) \subseteq Z(N)$, and the equation above is precisely the equation of a "Derivation of $G/N$ into $Z(N)$ consistent with the given action of $G/N$ on $Z(N)$ (by conjugation)". In the notation above, $\alpha$ is the "outer" action of $G/N$ on $N$, which induces an actual action on $Z(N)$, and the notation $Z^1_\alpha(G/N, Z(N))$ is precisely this set of derivations.
What Wells actually did was to show that we can replace $\Aut(N) \times \Aut(G/N)$ with its subgroup $C$ of "compatible pairs" (the notion of compatibility just depends on the action $\alpha$), and then extend this exact sequence with an additional map $C \to H^2_\alpha(G/N, Z(N))$. Malfait further expanded this into a 27-term commutative cube diagram.
There's a really great summary of work on this exact sequence and its extensions by Jill Dietz, that also highlights the role of Buckley's group action in this (and related) sequences.