Let $E, F$ be Banach spaces. A continuous bilinear functional ${\langle \cdot\,, \cdot \rangle }: E \times F \to \mathbb{R}$ is called $E$-non-degenerate if $\langle x,y\rangle = 0$ for all $y \in F$ implies $x=0$ (Similarly for $F$-non-degenerate). Equivalently, the two maps of $E$ to $F^{*}$ and $F$ to $E^{*}$ defined by $x \mapsto \langle x, \cdot \rangle$ and $y \mapsto \langle \cdot\,, y\rangle$, respectivelly, are one-to-one. If they are isomorphisms (*), $\langle \cdot\,, \cdot \rangle$ is called $E$ or $F$-strongly non-degenerate. We say that $E$ and $F$ are in duality if there is a non-degenerate bilinear functional $\langle \cdot\,, \cdot \rangle: E\times F \to \mathbb{R}$, also called a *pairing* of $E$ with $F$. If the functional is strongly non-degenerate, we say the duality is strong.

Consider the following definition.

**Definition:** Let $E$ and $F$ be normed spaces and $\langle \cdot, \cdot \rangle$ a $E$-non-degenerate pairing. Let $f: F \to \mathbb{R}$ be Fréchet differentiable at the point $\alpha \in F$ (denote this derivative as $Df(\alpha)$). The functional derivative $\delta f/\delta \alpha$ of $f$ with respect to $\alpha$ is the unique element in $E$, if it exists, such that:
\begin{eqnarray}
Df(\alpha)(\gamma) = \left\langle \frac{\delta f}{\delta \alpha}, \gamma\right\rangle\quad\forall\gamma \in F. \tag{1}\label{1}
\end{eqnarray}

Now, I'd like to know how to define higher order derivatives of functional derivatives. In other words, suppose the Fréchet derivative of $f$ at $\alpha$, $Df(\alpha)$ is Fréchet differentiable at $\beta\in F$, is it possible to define $\dfrac{\delta^{2}f}{\delta \beta\delta\alpha}$?