In an interview (I link the Google translation), Voevodsky talks about how, in the late 2000s, he worked on the problem of "restoring the history of populations according to their modern genetic composition". Some of his unpublished papers on this topic are now available online. For example, a paper titled "Singletons" is available on the IAS website. Why did Voevodsky abandon the subject of this rather fleshed-out paper so suddenly?
As a result, I chose, as I understand correctly now, the problem of restoring the history of populations according to their modern genetic composition. I was busy with this task for a total of about two years and in the end, already in 2009, I realized that what I had invented was useless. In my life, for now, this was probably the biggest scientific failure. A lot of work was invested in the project, which completely failed. Some benefit, of course, nevertheless, was - I learned a lot from probability theory, which I did not know well, and I also learned a lot about demography and demographic history.