1
$\begingroup$

I'm studying a simplification of a biological neuron model with $n$ neurons. We are describing the evolution of the membrane potential of each neuron. Let $(X_t)_{t\geq 0}$ be a Markov Jump Process in $\mathbb{N}_0^n$ with the following generator $Q$:

\begin{equation} \begin{cases} (i)\ \ \ \ q(x,(x)_i^c) = b(x_i) \\ \\ (ii)\ \ \ q(x,x+e_i)=\lambda x_i\ \ \ \ i=1,...,n \\ \\ (iii)\ \ q(x,x-e_i) =\mu x_i \end{cases} \end{equation}

Where $(x)_i^c: = x+c(1,...,1)-(x_i+c)e_i\ \ \ (c\in \mathbb{N})$; $\ \ \mu > \lambda\ $; and $b:\mathbb{R}_{\geqslant 0}\to \mathbb{R}_{\geqslant 0}$ is a non-negative, non-decreasing function with $b(0)=0$.

Looking carefully at $(x)_i^c$, you can see that it represents the discharge of neuron $i$. It goes to zero, whereas the other neurons recieve a fixed potential $c>0$.

The goal is to prove that this process has almost certain extinction. That is, we need to prove that

$$ \mathbb{P}(T_0<+\infty) =1 $$

Where $T_0:=\inf\{t>0:X_t=(0,...,0)\}$

Here are some observations and an idea of what may be a path towards a proof:

For a start, see that if we ignore condition $(i)$, then $(ii)$ and $(iii)$ represent in each coordinate an independent Birth-and-Death process in $\mathbb{N}_0$ with almost certain extinction, so if we ignored $(i)$ then we would have almost certain extinction for $(X_t)$.

I expect that the perturbation introduced by $(i)$ does not affect so much: What $(i)$ says is that when a coordinate is too "high", then it increasingly tends to "discharge". The total potential $||X_t||_1$ is increased by $c(n-1)$ and decreased by $x_i(t)$, so it only increases if the potential $x_i(t)$ was below the threshold $c(n-1)$. A discharge of a neuron with such a potential occurs with rate at most $b(c(n-1))$.

The idea I have for a proof is to define some neighborhood around $(0,...,0)$ (say $\mathcal{C}:=\{ ||X||_1 \leqslant k\}$ for some $k>0$) where I can have positive probability of extinction $p$, independently of the starting point. And then I'd like to prove that if you are out of $\mathcal{C}$, then you come back with probability 1.

Finally I would define an associated random variable with Geometric distribution $p$ , thinking as the experiment " whether or not $(X_t)$ starting inside $\mathcal{C}$ reaches extinction".

Are my ideas correct?

What about the idea of a proof?

If correct, are there some details I need to be careful with?

EDIT 1: I've already proved that

$$ \mathbb{P}_x(T_{\mathcal{C}}<+\infty) = 1 \ \ \ \forall x\notin \mathcal{C}$$

Where $\mathcal{C}=\{x\in\mathbb{N}_0^n:||x||_1\leqslant K \}$ for some $K>0$ (which is a finite set).

Now the issue would be to write properly the idea that I've exposed above.

$\endgroup$

1 Answer 1

3
$\begingroup$

Did you mean $\lambda < \mu$? (As you stated the question, the birth/death process ignoring discharges grows to infinity.) Also, is $n = N$, is $c$ an integer, and is $X$ constrained to be nonnegative coordinate-wise?

I'm going to assume the answer to all the above questions is "yes". In that case, your approach looks exactly right. Let $\mathcal{C}$ be the set where neuron discharge can increase $\|X\|_1$. If you're outside $\mathcal{C}$, then $\|X\|_1$ is dominated by a birth/death process, which means that in finite expected time you'll re-enter $\mathcal{C}$. Since $\mathcal{C}$ is finite, this means $X$ is positive recurrent, i.e. gets absorbed at 0.

If $c$ is rational, the argument stays essentially the same (just multiply everything through by the denominator of $c$). If $c$ is irrational, as stated it's impossible to reach the 0 state after a neuron discharge happens, since coordinates can be changed only by multiples of 1 and $c$. You still have the result that you'll return to the compact neighborhood $\mathcal{C}$ of the origin infinitely often and in finite expected time, but you'll need to do something to make sure 0 is reachable from all of $\mathcal{C}$.

$\endgroup$
6
  • $\begingroup$ Thank you for the answer. I've already edited my question to correct what you pointed out. And I'll write down the proof properly with this idea and your comments. $\endgroup$
    – Max
    Sep 14, 2017 at 17:11
  • $\begingroup$ I've got a question regarding your answer. You said $\mathcal{C}$ is finite, but as you defined $\mathcal{C}$ ( the set where neuron discharge can increase $|| X ||_1$ i.e., where there exists $i$ such that $x_i < c(n-1)$) it is not finite $\endgroup$
    – Max
    Sep 14, 2017 at 18:02
  • $\begingroup$ How do you think this could be fixed? $\endgroup$
    – Max
    Sep 14, 2017 at 18:08
  • $\begingroup$ Oh, good point. On the other hand, the rate at which $\|X\|_1$ goes up (by at most $cn$) through this mechanism is bounded above by $b(n)$, which will become negligible relative to to the birth/death dynamics for $\lambda < \mu$ when $\|X\|_1$ is large enough. (That is, your BDP will -- eventually -- be dominated by a BDP with a slightly larger value of $\lambda$ and slightly odd offspring.) $\endgroup$ Sep 15, 2017 at 14:15
  • $\begingroup$ Could you explain to me why you say that the rate at which $||X||_1$ goes up through this mechanism is bounded above by $b(n)$? The closer true statement I can think of is that it is bounded by $b(c(n-1))$ inside a modified $\hat{\mathcal{C}}$ the finite set where $x_i\leqslant c(n-1)\ \forall i$. Maybe you are assuming something I'm not seeing. $\endgroup$
    – Max
    Sep 18, 2017 at 20:01

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.

Not the answer you're looking for? Browse other questions tagged or ask your own question.