Let $\mathbb{R}$ denote the real line with its usual topology. Does there exist a sheaf $F$ of abelian groups on $\mathbb{R}$ whose second cohomology group $H^{2}\left(\mathbb{R},F\right)$ is non-zero? What about $H^{j}\left(\mathbb{R},F\right)$ for integers $j\ge 2$ ?
(Here cohomology means derived functor cohomology as in, say, Hartshorne or EGA. Anyway this cohomology coincides with Cech cohomology since $\mathbb{R}$ is paracompact.)