The following wonderful paper:
Manfred Droste, Michèle Giraudet, Rüdiger Göbel, All Groups are Outer Automorphism Groups of Simple Groups Journal of the London Mathematical Society 64 (2001) 565–575, doi:10.1112/S0024610701002484
shows that every group $G$ is isomorphic to $\mathrm{Out}(H)$ for some simple group $H$. The natural question arises about how unique this prescription is. What can be said about two simple groups (usually infinite in my case) with the same outer automorphism group? Anything along the lines of Morita/monoidal Morita or similar equivalence?
I am interested in a general answer, of course. But partial answers and comments are also welcome. Please, note that I am not an algebraist, so even if the answer involves advanced notions, I would appreciate a description of those as simple as possible. Thank you.