In the paper
Cordier, Jean-Marc, and Timothy Porter. "Homotopy coherent category theory." Transactions of the American Mathematical Society 349.1 (1997): 1-54.
the authors define a notion of coherent co/end $\oint T(a,a)$ as $$ \int_{a',a''} T(a',a'')^{\delta A(a',a'')} $$ where $\delta A(a',a'')$ is a suitable "resolution" of the hom functor (linked to the bar construction; follow §1, and in particular the paragraphs above Definition 1.1).
The main claim of this paper is that category theory can be rewritten in a homotopy coherent fashion, building on this definition of homotopy coherent co/end. It is obvious why I like this point of view :-)
One of the first interesting claims is the following: fix a simplicial functor $F : A \to B$ between simplicial categories, and define $$ \begin{gather} \overline F = \{\delta A(a,-),F\} = \oint_{x:A} Fx^{A(a,x)}\\ \underline F = \delta A(-,a)\otimes F = \oint^{x:A} Fx \otimes A(x,a) \end{gather} $$ This is the counterpart of the "ninja Yoneda lemma" in covariant and contravariant form.
Coend-fu now gives that "underlines and overlines absorb coherence" in that $$ \text{CohNat}(F,G) \cong \text{Nat}(F, \overline G)\cong \text{Nat}(\underline F,G) $$ This gives natural transformations $$ \eta_F : F \Rightarrow \overline F \qquad\qquad \eta^F : \underline F \Rightarrow F$$ as the images of the identity coherent natural transformation of $F$. The authors then prove that these maps are levelwise homotopy equivalences (Prop. 3.4).
Are $\overline F, \underline F$ replacements for $F$ in suitable model structures on categories of functors? Is $\overline F$ fibrant if $F \in [A, {\bf sSet}]_\text{inj}$? Is $\underline F$ cofibrant if $F \in [A, {\bf sSet}]_\text{proj}$?