Let $M$ be a model category and $S \subseteq \operatorname{Mor}(M)$ a set of arrows in (the underlying strict category of) $M$. Recall that the left Bousfield localization $L_SM$ of $M$ with respect to $S$ is the model category structure on the same underlying category as $M$, with the same cofibrations, more weak equivalences, and correspondingly fewer fibrations; it is the universal model category structure with these properties in which the elements of $S$ are weak equivalences.
Let $M^\Delta$ denote the category of simplicial objects in $M$. It has two related model category structures: the injective one, in which cofibrations and weak equivalences are "levelwise" (and hence fibrations are complicated), and the projective one, in which fibrations and weak equivalences are levelwise (and cofibrations are more complicated). I am interested in both structures, so in some sense this question is really two questions.
Question: Is $(L_SM)^\Delta$ a left Bousfield localization of $M^\Delta$? What is an explicit description of the maps at which you localize?
I expect the answer is "yes", and that you can localize at the set of maps in $M^\Delta$ that are levelwise in $S$. These seems like the type of thing that should be provable by definition unpacking. But I got stuck somewhere, suggesting that maybe there is a subtlety. The worry is that perhaps there just aren't a lot of levelwise-$S$-maps in $M^\Delta$, so that testing just against the levelwise-$S$-maps might give false positives when you are trying to find out if an object is levelwise-$S$-local.