Invariant definition of the space of symbols on a vector bundle (pseudo-differential operators) Normally, in the context of pseudo-differential operators, a symbol on a vector bundle $E$ is defined as a smooth function on $E$ which in each trivializing chart fulfills the usual symbol estimates 
\begin{equation}
\sup_{x \in U, \xi \in \mathbb{R}^p} (1 + |\xi|^2)^{\frac{-m + |\beta|}{2}} \ |D^\alpha_x D^\beta_\xi a(x, \xi)| < \infty.
\end{equation}
Does there exists a definition which does not directly rely on a local trivialization?
Note that classical symbols (symbols with an asymptotic expansion at infinity) can be interpreted as smooth functions on the (radial) compactification and thus for them there is a nice coordinate-free interpretation (I think this approach is publicized by Richard Melrose). Something along these lines would be perfect, but a definition based on additional data (like choosing a fiber metric and/or connection) is also ok.
 A: I think the following should work:
Let $M$ be a compact manifold (just to be safe) and $\pi :E \to M$ a vector bundle. Since $E$ carries an action of $\mathbb{R}^{\times}$ there's an invariant notion of a function on $\overset{\circ}{E}$ ($E$ without the zero section) which is homogeneous of degree $s$ for every $s \in \mathbb{R}$ namely:
$$\{ f: \overset{\circ}{E} \to \mathbb{R} | f(\lambda v) = |\lambda|^s f(v) \}$$
Using this we can define what it means for a function to have growth of degree $\le s$. Namely you just take those functions $f$ on $E$ s.t. $f = O(\psi)$ for some homogeneous function $\psi$ of degree $s$ (where the $O$ notation is supposed to be interpreted fiberwise and not in the $M$-direction). 
All that's left now is to take care of derivatives but the vertical subbundle $VE \subset TE$ is always globally well defined (as it is the kernel of the pushforward of tangent vectors). Moreover we can also consider vertical vector fields which are invariant w.r.t. the action of $E$ on itself by vector addition. That is 
$$C^{\infty}(E,VE)^E = \{X \in C^{\infty}(E,VE) | \forall u \in C^{\infty}(M,E), t_{\pi^*u}^* X = X\}$$
Where $t_{\pi^*u}^*$ is the pullback along the tranlsation by $\pi^*u$. Call these vertical vector fields linear. In local coordinates these are the vector fields which are constant along the fibers.
Now we can say that a function $f$ on $E$ is of symbol class $\le m$ iff for every collection of $r$ linear vector fields the growth of the iterated derivative w.r.t. these vector fields is of degree $\le m-r$. This definition is obviously local on $M$ and it also recovers your definition in the case of the trivial vector bundle so it must coincide with it in the global case, i hope i'm not wrong...
