As someone who mostly does symbolic computation, I've always been puzzled by the fascination mathematicians seem to have with Lp(R) (for p<∞)? To be more precise, there are no non-trivial polynomials in that space and, to me, polynomials are not only the simplest functions, they are the building blocks of most everything which can be (easily) manipulated algorithmically. And restricting to a compact support is really a non-answer, since one of the great things about polynomials is that they are global, analytic functions.
To ask a more precise question: are there some spaces of (total, real-valued) functions which are both nice from a functional analysis point of view, and contain all the polynomials?