Space of differential operators Let $A$, $B$ be two smooth vector bundles of finite rank over a smooth manifold $M$. Let $Diff(A,B)$ be the space of differential operators from $A$ to $B$. Can I talk about "the space of smooth maps from $[0,1]$ to $Diff(A,B)$? 
 A: You could use the bijective correspondence between differential operators $L: \Gamma(A) \to \Gamma(B)$ and vector bundle homomorphisms $\tilde{L}: J^k A \to B$ to topologize your space $Diff(A,B)$. Then $C^1$-curves in $Diff(A,B)$ are defined as usual, that is, the differential quotient has to exist and be continuous. Iterating yields the notion of smooth curves.
A: One way to introduce the space you are interested in is:
$$
\widetilde{\textrm{Diff}}(A,B):=C^\infty([0,1])\otimes_{\mathbb{R}}\textrm{Diff}(A,B).
$$
I'm sure this approach is equivalent to the topological one, suggested by @Tobias, at least for operators of bounded order.
You can also characterize it as a distinguished subspace
$$
\widetilde{\textrm{Diff}}(A,B)\subseteq \textrm{Diff}(p^*A,p^*B).\quad\quad\quad (*)
$$
Indeed, if $\{\alpha^i\}$ (resp., $\{b_j\}$) is a basis of $\Gamma(A)^*$ (resp., $\Gamma(B)$), then
$$
L=L_{i\, I\, l}^j\cdot b_j\otimes \frac{\partial^{|I|+l}}{\partial x^I\partial t^l}\circ \alpha^i
$$
is the local expression of a generic element $L$ belonging to the right--hand side of $(*)$, which sits in the left--hand side if and only if $L_{i\, I\, l}^j=0$ for $l>0$, i.e., as you said, $L$ is of order 0 along the fibers of $p$.
P.S. I used coordinates $x^i$ on $M$ and $t$ on $[0,1]$; $I$ is a multi-index of length $|I|\leq k$, and $L_{i\, I\, l}^j\in C^\infty(M\times [0,1])$; I tacitly used the same bases for $A$ and $B$ and their pull-backs (it is only the algebra of scalars which grows bigger).
