As mentioned by Conrad in the comments, your first statement is a theorem by Neukirch-Uchida (Neukirch-Ikeda-Iwasawa-Uchida, according to some sources).
Your second question is much more complicated, depending on how it is interpreted. As stated the answer is "yes, in fact infinitely many by Neukirch-Uchida".
But if you mean if we know a concrete profinite group $G$ such that $G\cong \mathrm{Gal}(\overline{K}/K)$ for some number field $K$, then the answer is "definitely no". But there are beautiful math behind this and related question, see for example the answers to this question of mine.
I'm not sure what you mean by "does the topology matter". I don't think there is an alternative to using the Krull topology or something equivalent, if you want a working infinite Galois theory.