In algebraic geometry, there are two standard "kinds" of divisors: Weil divisors and Cartier divisors. Weil divisors provide better geometric intuition, while Cartier divisors are more general (if not precisely a generalization). In both of these kinds of divisors, the "key" results seem to be their relation to the Picard group (of isomorphism classes of line bundles).
However, one could also define a "divisor" to be an equivalence class of pairs $(s, \mathcal{L})$, where $s$ is an invertible rational section of $\mathcal{L}$. (By "invertible" I mean that there exists a rational section $s'$ of $\mathcal{L}^{\vee}$ such that $s' s = 1$.) We say $(s, \mathcal{L}) \sim (s', \mathcal{L}')$ if there is an isomorphism $\mathcal{L} \to \mathcal{L}'$ taking $s \mapsto s'$.
This definition works well at least for all Noetherian schemes (on which associated points behave nicely), and possibly more generally. It also seems less confusing than the definition of a Cartier divisor, and the relationship between divisors and line bundles is already embodied in the definition.
So why have I never seen this definition given as a kind of divisor?
[Note: I am aware of what "data" defines a Cartier divisor (the $(U_i, f_i)$, etc.) and how this provides a reasonably natural way to think of Cartier divisors geometrically (the "subscheme" defined locally by the $f_i$). So while I appreciate the thought, please don't waste your time writing a note for the sole purpose of explaining this.]
Edit: Since this issue has come up in an answer, I thought I would explain that by "rational section," I mean a (maximally extended) section over an open subset containing all the associated points; or equivalently, a section of $\mathcal{K} \otimes \mathcal{L}$, where $\mathcal{K}$ is the sheaf of total quotient rings of $\mathcal{O}_X$. (Actually, $\mathcal{K} \otimes \mathcal{L}$ is isomorphic to $\mathcal{K}$, but not naturally so.) A rational section can fail to be invertible if it vanishes on one or more associated points.
