Let $\beta \in L^\infty(\mathbb{R} ; (0, \infty))$ be bounded from above and below by positive constants. Consider the self-adjoint operator $ -\beta^{-1} \partial^2_x : L^2(\mathbb{R}; \beta dx) \to L^2(\mathbb{R}; \beta dx)$ with domain the Sobolev space $H^2(\mathbb{R})$.
If $1 - \beta(x)$ decays sufficiently fast as $|x| \to \infty$, is the spectrum of $-\beta^{-1} \partial^2_x$ discrete in $(-\infty, 0)$? If so, are there only finitely many negative eigenvalues?
This sort of result is well known if we are instead considering the operator $-\partial^2_x + V(x) : L^2(\mathbb{R}) \to L^2(\mathbb{R})$ with potential $V \in L^\infty$ decaying fast enough toward $\pm \infty$. In that case, the standard argument to show discreteness of spectrum uses the resolvent identity:
\begin{equation*} (-\partial^2_x + V - \lambda^2)(\partial^2_x- \lambda^2)^{-1} = ( \text{Id} + V (-\partial^2_x -\lambda^2)^{-1}), \qquad \text{Im}\, \lambda > 0. \end{equation*}
The operator $V (-\partial^2_x -\lambda^2)^{-1}$ is compact, thanks to the sufficient decay of $V$, and has norm less than one for $\text{Im} \lambda \gg 1$. Hence (using a Neumann series) $(-\partial^2_x + V - \lambda^2)^{-1}$ exists for $\text{Im} \, \gg 1$, and (by the Analytic Fredholm Theorem) exists as meromorphic operator in $\text{Im}\, \lambda > 0$.
This argument seems to break down for the higher order perturbation of $-\partial^2_x$. Noting that $(-\beta^{-1} \partial_x^2 - \lambda^2)^{-1}$ exists and is bounded if and only if $(-\partial_x^2 - \beta \lambda^2)^{-1}$ exists and is bounded, the analogous resolvent identity seems to be \begin{equation*} (-\partial^2_x - \beta \lambda^2)(-\partial^2_x - \lambda^2)^{-1} = \text{Id} + (1 - \beta) \lambda^2 (-\partial^2_x - \lambda^2)^{-1}. \end{equation*}
This issue now seems to be that the extra factor of $\lambda^2$ precludes us from concluding that the norm of $(1 - \beta) \lambda^2 (-\partial^2_x - \lambda^2)^{-1}$ is small for $\text{Im} \gg 1$, and hence we cannot construct $(-\beta \partial^2_x - \lambda^2)^{-1}$ by a Neumann series.