The following question on polynomials arose as a potentially helpful intermediate step on a proof of a Theorem that I want to demonstrate. Its statement is quite elementary, and I can think of a number of applications it might have to the study of Hilbert polynomials in commutative algebra and certain combinatorial sequences arising in discrete geometry.
Conjecture 1: Let $(c_0,\ldots,c_n)$ be non-negative integers and consider the polynomial $P(x) = \sum_{i=0}^n c_i \binom{x+n-i}{n}$. Assume that $P(x)$ has at least one negative real-root and denote by $-r$ the largest (in absolute value) negative real-root of $P(x)$. Then either $\lfloor r \rfloor = 0$ or $-\lfloor r\rfloor$ is a root of $P(x)$ too.
A weaker statement that could also be useful:
Conjecture 1': Let $(c_0,\ldots,c_n)$ be non-negative integers and consider the polynomial $P(x) = \sum_{i=0}^n c_i \binom{x+n-i}{n}$. If $P(-1)\neq 0$, then the negative real roots of $P(x)$ (if any) lie in the interval $(-1,0)$.