This is a partial answer. I tried to mimic the proof of Theorem 3 in
[1] Complete lattices and the generalized Cantor theorem by Roy O. Davies, Allan Hayes and George Rousseau, published in Proc. Amer. Math. Soc. 27 (1971), 253–258.
(The notation used in this answer is different from the one in the question. I'll stick as much as possible to the notation and terminology of [1].)
All categories in this post are small.
Let $A$ and $B$ be categories, and let $b_0,b_1$ be two objects of $B$ such that there is a morphism $b_0\to b_1$ but no morphism $b_1\to b_0$.
We claim
(1) $B^B$ is not equivalent to $B$,
(2) there is no full functor $B^A\to A$ and no essentially surjective functor $A\to B^A$.
It suffices to prove (2).
For any category $C$ write $C_0$ for the set of objects of $C$.
Let $C$ and $D$ be categories. Say that a map $F:C_0\to D_0$ is a weak monomorphism if the existence of morphisms $c\to c'$ and $F(c')\to F(c)$ implies that of a morphism $c'\to c$.
It is clear that the map $C_0\to D_0$ induced by a full functor is a weak monomorphism. It is also clear that the existence of an essentially surjective functor $D\to C$ implies that of a weak monomorphism $C_0\to D_0$.
We claim
(3) There is no weak monomorphism $(B^A)_0\to A_0$.
It suffices to prove (3).
Let $2$ be the ordinal $\{0,1\}$ viewed as a category. We claim
(4) There is no weak monomorphism $(2^A)_0\to A_0$.
Let us show that (4) implies (3).
Let $F:(B^A)_0\to A_0$ be a weak monomorphism, let $J:2\to B$ be a functor mapping $i$ to $b_i$ for $i=0,1$ (such a functor exists by assumption), and define $F':(2^A)_0\to A_0$ by $F'(G):=F(J\circ G)$. It is straightforward to check (using the assumption that there is no morphism $b_1\to b_0$) that $F'$ is a weak monomorphism (details left to the reader). This proves that (4) implies (3).
It suffices to prove (4).
Say that a subset $R$ of $A_0$ is a right ideal if the conditions $a\in R$ and there is a morphism $a\to a'$ imply $a'\in R$. The right ideals form a complete lattice $\mathcal R$ order isomorphic to $(2^A)_0$. (The order on $\mathcal R$ is given by inclusion.)
Thus it suffices to show that there is no weak monomorphism $\mathcal R\to A_0$.
Let $\phi:\mathcal R\to A_0$ be a map. Define the map $f:\mathcal R\to \mathcal R$ by letting $f(R)$ be the right ideal generated by $\phi(R)$. By the corollary to Theorem 1 in [1] there is an $R$ in $\mathcal R$ such that
$$
f(R)\le\bigcup_{S>R}f(S).
$$
As we have $\phi(R)\in f(R)$, this implies $\phi(R)\in f(S)$ for some $S$ in $\mathcal R$ with
(5) $R<S$,
and thus (by definition of $f(S)$) the existence of a morphism
(6) $\phi(S)\to\phi(R)$.
Now (5) and (6) imply that $\phi$ is not a weak monomorphism.