Thom's theorem states that for every homology class $\alpha \in H_{*}(X)$ there exists an integer $k = k(\alpha)$ such that the class $k\, \alpha$ comes from the fundamental class of an orientable closed smooth manifold, where $X$ is an arbitrary topological space. To be on the safe side we assume that $X$ is a countable CW-complex.
Given a topological pair $(X,A)$, $A$ is closed, and a homology class $\alpha \in H_{*}(X,A)$. Is it possible to realize $k\, \alpha$ by a map from an orientable manifold with boundary, for $k$ sufficiently large?