Let $A$ be a square matrix of order $n$, say with complex coefficients, and let $M$ be the plain matrix of minors of $A$ of order $n-1$ (no transpose, no sing changes). Let $I$ and $J$ be $r$-subsets of the index set $[n]$. Then, apparently $$\det M_{I\times J}=\det A_{([n]\setminus I)\times ([n]\setminus J)}\det(A)^{r-1}.$$ (One can also write the identity for the classical adjoint of $A$ instead of $M$, or also assume $A$ invertible, and express the identity in terms of $A^{-1}$).
So for $r=1$ this is just the definition of $M_{ij}$. For small values of $n$, it is possible to check the identity, keeping track of the terms of the expansion of the determinant. But is there a more synthetic proof, and an interpretation of it?