$\exists p, q \in \mathbb{P}: p^4+1 = 2q^2$? I suspect there is some simple proof that no such p, q can exist, but I haven't been able to find one.
Solving the Pell equation gives candidates for p^2=x and q=y, with x=y=1 as the first candidate solution and subsequent ones given by x'=3x+4y, y'=2x+3y; chances of a prime square seem vanishingly unlikely as x increases, but I don't have a proof.
Meta: how do you search for a question like this? I looked for a searching HOWTO here and on meta, and couldn't find one. That the search appears to strip '^' and '=' makes it all the harder.