To add to Ryan's answer,

$2$--knots usually don't have aspherical complements, see Dyer & Vasquez, The sphericity of higher dimensional knots, Canad. J. Math. 25(1973), 1132-1136. Which suggests a complicated answer for slice disks in general.

On the other hand, if the disk is ribbon, then the complement is aspherical, see Asano, Marumoto, and Yanagawa, T, Ribbon knots and ribbon disks, Osaka J. Math. 18 (1981), 161-174

To add to Ryan's answer,

$2$--knots usually don't have aspherical complements, see Dyer & Vasquez, The sphericity of higher dimensional knots, Canad. J. Math. 25(1973), 1132-1136. This suggests a complicated answer for slice disks in general.

On the other hand, if the disk is ribbon, then the complement is aspherical, see Asano, Marumoto, and Yanagawa, T, Ribbon knots and ribbon disks, Osaka J. Math. 18 (1981), 161-174