The asymptotic number of $m$-regular graphs on $N$ vertices is well understood and can be found, for example, in Bollobas' Random Graphs (the argument uses Bollobas' "configuration model"). With probability $1$ a graph has no automorphisms, so this is also the number of isomorphism classes as long as $N$ is large. In your case $N=(2n+1^m.$$N=(2n+1)^m.$ So, for a reasonably sized $n$ (since yours is a natural number, $n>0$ should be fine), if you pick two random graphs, they will be non-isomorphic.