The moduli space ofof stable 2$2$-pointed genus 1$1$ curves has cyclic quotient singularities, so any Weil divisor on $\overline{M}_{1,2}$ is $\mathbb{Q}$-Cartier.
Is one of the two boundary divisors $\Delta_{irr}$ and $\Delta_{0,2}$ of $\overline{M}_{1,2}$ Cartier ?