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Nov 7, 2009 at 6:58 comment added Tom Church Yes. There is a subset U of R^4 which is an open submanifold and, with the induced topology, homeomorphic to R^4; however, the induced smooth structure on U coming from the standard smooth structure on R^4 makes U not diffeomorphic to the standard R^4. Such spaces are called "small" exotic R^4's, see e.g. en.wikipedia.org/wiki/Exotic_R4.
Nov 7, 2009 at 4:33 comment added Oliver Ok, but there is something I don't really understand : is the exotic smooth R^4 open subset of R^4 you consider provided with the differential structure induced by the standard R^4 ? Recall that I consider in my question only one differential structure (the standard one) on U and R^4.
Nov 7, 2009 at 3:57 comment added Ryan Budney Nope. As I mentioned earlier, there are exotic smooth R^4's that embed smoothly in R^4. So such open subsets of R^4 are contractible and simply connected at infinity (since they're homeomorphic to R^4), but not diffeomorphic to the standard R^4 as that's what "exotic smooth R^4" means.
Nov 7, 2009 at 3:48 history answered Oliver CC BY-SA 2.5