The answer given by @user1504 to the question [1] illustrates in a clear way, (being a profane in quantum theory, I could be mistaken), the link between the problem of Mass-Gap and the mathematics, including the holomony, the theory of hilbertian measured spaces...
However, continuing with the example of the geometry defined by a metric, the quantisation of such theory corresponds to the quantisation of gravitation (at least when the metric is lorentzian). In this context, a link between the Mass-Gap problem and mathematics is the proof by an effective method (quantification method), of the positive mass theorem. The positivity of the mass is intimately linked to the problem of the classification of differential varieties. This classification involves the most sofisticated devices of geometric analysis such as: the Atiyah-Singer index theorem, the Dirac operators, Seiberg-Witten operators, the variation calculus, the Ricci Flow, ... Cf [2; 3; 4].
Note. The positive mass theorem of J. Lohkamp asserts that: under the hypothesis of the dominant energy condition, the total mass for any casenon-vacuous isolated relativistic gravitational systems should be positive. Cf introduction of [3] for a bright presentation of all of concepts (and very more). It's at this point, I think (and if I well understand the answer of @user1504 given to the question [1]), that a constructive proof (quantised proof) of a positive mass theorem (perhaps without any hypothesis on the energy regime) is linked (is equivalent?) to the Mass-gap problem for the quantised gravity (if any...).
I would like to thank very much @user1504 for his answer to question [1] and for his remark on the previous version of this answer.
The quantum theory seems so fascinating, unfortunately, it falls out of my field of competence (for now).
As I said in the previous version of this answer, these ideas are borrowed from the works of so many geometers that I can not precisely say of whom these ideas are (if I have grasped something about these works).
That
However, I will name a few, without any intention to underestimate someone (by omission): A. Banyaga, R. Bryant, Y. Choquet-Bruhat, D. Christodoulou, P. T. Chrusciel, S. Donaldson, M. Gromov (The Father-Christmas in problems and results of geometry), N. Hitchin, S. Klainerman, C. LeBrun, P. Michor, R. Penrose, S. T. Yau.
That they all, all my recognition and my admiration.
[1 ]Statement of Millenium Problem: Yang-Mills Theory and Mass Gap
[2 ]https://arxiv.org/pdf/1704.05490