If you try to create a regularregularly spaced lattice in 3-dimensions such as $\mathbb{R}^3$, a starting point would be the regions of $\mathbb{Z}^3$ which are enclosed by the object in question. That would be the lattice containwhich contains a point at every integer value of $x, y, $ and $z$ within the object's boundaries. If you connect an edge between every two lattice points that are Euclidean distance $1$ apart, $(\Delta x)^2+(\Delta y)^2+(\Delta z)^2 = 1$, then each vertex will have six edges from it leading to the six lattice points at the relative positions $\Delta x=-1$, $\Delta x=+1$, $\Delta y=-1$, $\Delta y=+1$, $\Delta z=-1$, $\Delta z=+1$.
Notice that the boundaries of such a mesh would be clipped and would not match the boundaries of the object. Such a mesh could be extended by having the outermost lattice-points moved from co-inciding with $(x,y,z) \in \mathbb{Z}^3$ to a position in $\mathbb{R}^3$ which is on the boundary of the object. Now, the lattice is no longer regular, but the vertex connectivity is still regular. (Alternatively, additional lattice points could be added on the object boundary in $\mathbb{R}^3$ and connected with the underlying regular lattice, leading to irregular vertex connectivity.)
This sort of connectivity6-connectivity at vertices in 3-dimensions for lattice simulations allows for simulations such as 3-d lattice Boltzman numerical simulations. This type of connectivity6-connectivity is also known as the Von Neumann neighborhood in cellular automata simulations, and in the 2-dimensional case the analogous 4-connectivity Von Neumann neighborhood for a point at $(a,b)$ are the lattice points $(a-1,b), (a+1,b), (a,b-1),$ and $(a,b+1)$.
If you take a solid object modeled asrepresented by a 3-d lattice and model applying a physical pressure to it, then the regular object modeled by a regular lattice with regular geometry will become deformed. The lattice points, originally defined as being located at integer values, can be allowed to move in $\mathbb{R}^3$, associating a real value for each of its 3-dimensional coordinates. Thus, deformation modeling can be carried out, such as when an automobile's fender changes its shape in response to a collision with another object.
WhatIn response to your comment about which is better, what is better has to be defined in terms of the end goal to be reached: numerical precision, model fidelity to the underlying physical objects, speed of computation.